We are actively seeking cats with stable CKD to participate in a mirtazapine clinical trial!

Mirtazapine has recently gained popularity in veterinary medicine due to the presence of several desirable effects, namely its significant anti-nausea, anti-vomiting and appetite stimulating properties. We believe that this medication will improve the appetite of cats who are “picky” eaters due to their CKD.

Eligibility:
Cats that have been diagnosed with stable CKD (not currently experiencing complications), have a creatinine between 2.8 and 5 mg/dl, and a “picky” appetite are potentially eligible for entry into the study. Exclusion criteria include other systemic illness (diabetes, inflammatory bowel disease, hyperthyroidism, cancer, liver disease, heart disease), complications of kidney disease such as kidney infection or decompensation, hospitalization and intravenous fluid therapy.  Other concurrent therapies such as diet, famotidine, potassium supplementation, and subcutaneous fluids are acceptable provided the treatment does not change during the study period.

Study Protocol:
This is a double-blind, placebo crossover study. The cat will have a complementary physical exam and chemistry panel at the beginning of the study. Mirtazapine or a placebo will be given every two days for three weeks. After this three-week period, there is a four day wash-out and a second physical exam and chemistry panel.  The cat will start another three weeks of mirtazapine or placebo. After completion of the second course the cat will receive another physical exam and chemistry panel. During each period the owner will be asked to fill out daily assessments of the cat’s habits, demeanor, appetite and any instances of vomiting.

This study can be performed at your clinic. You will receive a $100 incentive for each cat enrolled and will be reimbursed $36 for each of the three exams required by the study.  The chemistry panels will be performed at CSU at no cost.

Owner compensation:
If the cat completes the study, the owner will receive complimentary cat food (Purina NF) for 6 months from the date of admission into the study in addition to the complimentary physical exams and labwork. A 2 month supply of the compounded appetite stimulant medication will also be supplied if the owner desires.