The immunodominat antigens to which antibodies are formed in these cats are α-enolase and Annexin A2, both of which are linked to autoimmunity and renal disease in humans. Recently, we have shown that cats administered FVRCP vaccines parenterally have higher levels of circulating antibodies to these antigens than do cats who were administered a FVRCP vaccine for intranasal administration.

We now have funding from the Morris Animal Foundation to study the presence of antibodies to α-enolase and Annexin A2 in azotemic and non-azotemic cats with known vaccine history. We are seeking blood samples from patients with a minimum of 5 years of vaccination history available. Qualified patients will receive a free serum biochemistry analysis and will help discover the cause of this frustrating syndrome.

 

For more information visit Center for Companion Animal Studies - Colorado State University